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KMID : 0357520070300030259
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Journal of Radiological Science and Technology
2007 Volume.30 No. 3 p.259 ~ p.263
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Labeling Efficiency of 99mTc-Labeled RBC Due to Labeling Time Change
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Dong Kyung-Rae
Kim Ho-Seong
Choi Seong-Kwan
Kim Ho-Seong
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Abstract
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For the preparation of -labeled RBC, of Stannous(II) chloride and of preparation was used. For finding out the effect of contrast agent, the blood samples were collected in three days, seven days, and 1 months after the diagnostic procedure. In the normal volunteer, the concentration of reducing agent and preparation time did not effect on the radiochemical yield. But in the patients, 10 mg of Stannous(II) chloride and 60 min incubation times was shown high radiochemical yield. Contrast agent has a significant effect on the radiochemical yield. Although the blood samples which were collected after seven days of diagnostic procedure did not effect on the radiochemical yield of -labeled RBC, but the radiochemical yield of -labeled RBC which was prepared with a sample of high concentration of contrast agent in blood led to low radiochemical yield. For these samples, the modified method showed high radiochemical yield than previous in vivo preparation method. The recommended method is followed. Blood collecting was performed at 30 minutes after injection of reducing agent, and it is centrifuged for removal of plasma. After addition of , sample reservoir was rotated. After addition of normal saline, and it is centrifuged for separation of saline. Then -labeled RBC was obtained after removal of saline.
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KEYWORD
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99mTc-labeled RBC, Radiochemical yield, Stannous Chloride
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